Trioday Tablet (Cipla) – Quick Reference Article
1. What Is Trioday?Trioday (Cipla Ltd.) is a fixed-dose combination (FDC) antiretroviral pill for HIV-1 infection. One tablet, once daily — simplifies treatment, boosts adherence, and lowers pill burden.2. What's Inside?Ingredient Strength ClassEfavirenz 600 mg NNRTILamivudine 300 mg NRTITenofovir DF 300 mg NRTIPackaging: White HDPE bottle, 30 tablets/box (30-day supply) .Manufacturer: Cipla Limited, Goa, India . Distribution varies (e.g., Phil Pharmawealth in the Philippines).3. How It WorksThree drugs, two classes, one goal — stop HIV from replicating.Efavirenz (NNRTI): Binds directly to reverse transcriptase enzyme → prevents RNA-to-DNA conversion.Lamivudine (NRTI): Mimics deoxycytidine → gets incorporated into viral DNA → chain termination.Tenofovir (NRTI): Mimics adenosine monophosphate → active metabolite tenofovir diphosphate → chain termination.Result: Synergistic viral suppression + lower resistance risk .4. What It's ForTreating HIV-1 infection in adults .Not a cure — chronic suppressive therapy.Helps: reduce opportunistic infections, raise CD4 counts, improve quality of life .5. Clinical BenefitsBenefit DetailsViral suppression Most patients reach 65): Limited data.8. Major Drug InteractionsEfavirenz affects CYP3A4 & CYP2B6. Avoid or monitor:Drug Class Examples RiskAntihistamines Astemizole, Terfenadine Cardiac arrhythmiasGI motility drugs Cisapride CardiotoxicityErgot derivatives Ergotamine Ergot toxicitySedatives Midazolam, Triazolam Respiratory depressionAntipsychotics Pimozide ArrhythmiasHerbal St. John's Wort ↓ Trioday efficacyAnticonvulsants Carbamazepine, Phenytoin Altered levelsAntifungals Ketoconazole ↓ Antifungal effectAntibiotics Rifampin, Clarithromycin Multiple interactionsAvoid alcohol – worsens side effects & liver damage .9. Dosage & AdministrationAdult dose: 1 tablet once dailyHow to take: Swallow whole, don't crush/chewWhen: Empty stomach, preferably bedtimeMissed dose: Take ASAP unless next dose is near → no double dosesOverdose: Seek immediate medical help10. Regulatory StatusPhilippine FDA registration: DR-XY47585 (issued Dec 7, 2021; valid until Dec 7, 2024) .Global access: Launched in Uganda (2015) to improve adherence .11. Price (India)₹2,365 – ₹3,455 per bottle of 30 tablets .Generic substitutes: Avonza, Telura, Vonaday, Dinmek.12. Patient Counseling Points (Quick Checklist)# Advice1 Take same time daily – don't skip doses2 This is not a cure – use safe sex3 Initial side effects improve in 2–4 weeks4 Don't stop without doctor's advice5 Regular blood tests (liver, kidney, viral load, CD4)6 Avoid pregnancy + 12 weeks after stopping7 Tell doctor all meds (including OTC & herbs)13. Bottom LineTrioday is a potent, convenient, affordable fixed-dose combination for HIV-1. It simplifies adherence, suppresses virus, and restores immunity. Not a cure, but a cornerstone of modern HIV care — especially in resource-limited settings where Cipla's pricing makes a difference.Must be prescribed & monitored by a qualified healthcare professional.References (Authentic & Unchanged)Philippine Food and Drug Administration. (2024). *FDA Verification Portal - Product Information DR-XY47585*. https://verification.fda.gov.ph/Farmako. (n.d.). Trioday Tablet - Uses, Side Effects, and Composition. https://farmako.in/Oddway International. (2024). Trioday Tablets - Product Information. https://www.oddwayinternational.com/Philippine Food and Drug Administration. (2021). *Human Drugs View - DR-XY47585*. https://verification.fda.gov.ph/IndiaMART. (n.d.). *Trioday 30 Tablets - Product Details*. https://www.indiamart.com/Oddway International. (2025). Efavirenz Lamivudine Tenofovir Tablets. https://www.oddwayinternational.com/PharmEasy. (2025). Trioday Bottle of 30 Tablets. https://pharmeasy.in/1mg. (n.d.). Trioday - Uses, Side Effects, Composition. https://www.1mg.com/Antiaids.org. (2015). Uganda makes new AIDS drug. http://old.antiaids.org/